Never fazed, rarely flummoxed, Novak Djokovic is collected in best-of-five-set matches — even when falling behind, as he has done repeatedly at this US Open.

No opponent, or the prospect of what is at stake, has been too much to handle. Not yet, anyway. And now he is two wins away from the first calendar-year Grand Slam in men’s tennis since 1969, along with a men’s-record 21st major championship overall.

Djokovic ceded the opening set for the third consecutive match at Flushing Meadows — and ninth time at a major in 2021 — but it didn’t matter, because he quickly corrected his strokes and beat No. 6 seed Matteo Berrettini 5-7, 6-2, 6-2, 6-3 in a quarterfinal that began Wednesday night and concluded after midnight Thursday.

During his on-court interview, Djokovic cut off a question, sensing where it was headed, and said: “Do not ask me anything about history. I know it’s there.”

As he came back and improved to 26-0 in Grand Slam play this season, Djokovic found every angle, thwarted every big Berrettini shot, and was so locked in he dove and dropped his racket during one exchange and scrambled, rose and reinserted himself in the point. He lost it, but the message to his foe was unmistakable.

After 17 unforced errors in the first set, Djokovic made a total of 11 the rest of the way.

“The best three sets I’ve played in the tournament, for sure,” he said.

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When Berrettini made one last stand, holding a break point while trailing 4-2 in the third set, Djokovic steadied himself. He let Berrettini put a backhand into the net, then conjured up a 121 mph ace and a forehand winner down the line to hold, and then pointed his right index finger to his ear — one of many gestures asking the 20,299 in the Arthur Ashe Stadium stands for noise.

Four minutes later, that set was his. And 42 minutes later, the match was.

“He has this ability — and probably that’s why he’s the best ever — just to step up his game, his level, all the time,” said Berrettini, who also lost to Djokovic after taking the first set of the Wimbledon final. “Doesn’t matter how well I play, he just plays better.”

Djokovic already earned trophies on the Australian Open’s hard courts in February, the French Open’s clay courts in June and Wimbledon’s grass courts in July.

He has added five victories on the US Open’s hard courts and now faces 2020 runner-up Alexander Zverev in Friday’s semifinals. If Djokovic can win that match and Sunday’s final, he will join Don Budge (1938) and Rod Laver (1962 and 1969) as the only men to claim all four major tennis singles trophies in one season. Three women have done it, most recently Steffi Graf in 1988; Serena Williams’ bid in 2015 ended in the US Open semifinals.

One more Slam title also will break the career mark Djokovic currently shares with rivals Roger Federer and Rafael Nadal.

Zverev, 24, goes into the semifinals on a 16-match winning streak, including a 1-6, 6-3, 6-1 semifinal triumph against Djokovic en route to the gold medal at the Tokyo Olympics.

“I’m pumped,” Djokovic said, looking ahead to what awaits. “The bigger the challenge, the more glory in overcoming it.”

The other men’s semifinal is No. 2 Daniil Medvedev, a two-time major finalist, against No. 12 Felix Auger-Aliassime. They won their quarterfinals Tuesday.

The No. 4-seeded Zverev advanced Wednesday afternoon by beating Lloyd Harris 7-6 (6), 6-3, 6-4.

Hours later, both Djokovic and Berrettini showed signs of nerves on a muggy evening with the temperature at 75 degrees and the humidity at 80%. Applause, whistles and roars preceded the initial serve, a 124 mph ace by Djokovic, a three-time US Open champion.

Banned from the tournament a year ago because of the coronavirus pandemic, fans are clearly enjoying being a part of it.

They created a fugue of competing chants of Djokovic’s nickname, “No-le! No-le!” and a shortened version of Berrettini’s first name, “Mat-te! Mat-te!” Some greeted Djokovic’s missed serves with claps, considered a no-no in this sport, and some — perhaps the same people — lamented Berrettini’s faults with a communal “Awwwww.”

Djokovic’s form was not at its finest early, with more mistakes than he could fathom — he rolled his eyes, put a palm to his forehead, muttered toward those in his entourage.

Berrettini used his 6-foot-5, 209-pound frame to generate punishing power in serves and forehands; Djokovic called him the “Hammer of Tennis.”

But if any player is equipped to dull that style, it’s Djokovic, whose instincts, reflexes, agility and mobility are superior. So he, unlike most other players, can return a 131 mph serve and not merely get it in play but do so with enough intention to lead to a missed backhand by Berrettini, as happened when Djokovic broke to lead 3-1 in the second set.

Still, Berrettini did manage to grab the 77-minute opening set.

“Probably every other player out there, I would have felt like, ‘OK, now I’m going to go. For sure he’s going to be tired, too, a little bit. I can kind of like [take] over with my game, with my energy and everything,'” Berrettini said. “With him, it looks like he doesn’t care.”

Djokovic pretty much confirmed that, saying: “I managed to forget about it, move on.”

He also lost the first set in the third round, against Kei Nishikori, and in the fourth, against Jenson Brooksby, before winning in four sets both times. He did that against Berrettini at Wimbledon, too.

“When I dropped the first set, I just went to a different level and I stayed there till the last point,” Djokovic said about his latest victory. “That’s something that definitely encourages me and gives me a lot of confidence.”

He cleaned up his act by cutting down on errors, with three in the second set and three in the third, during which the retractable roof was shut because of expected rain.

Just holding serve became an ordeal for Berrettini, so much so that he let out a sigh of relief when he finally held after getting broken three times in a span of four games across the middle two sets. By then, though, he had given away the second and had fallen behind 3-0 in the third. The fourth also reached that score, and Djokovic was one step closer to his goals.

“Of course I’m aware of the history, of course it gives me motivation,” Djokovic said at his news conference, explaining why he cut off the on-court question. “If I start to think about it too much, it burdens me mentally. I want to really go back to the basics and what really works for me mentally.”

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